The OpenClaw Ecosystem for Scientific Research

OpenClaw

323K

The core platform. Personal AI assistant connecting 20+ messaging apps (WhatsApp, Telegram, Slack, Discord, Signal, iMessage, Teams, Matrix, Feishu, LINE). Voice support on macOS/iOS/Android with live Canvas rendering.

NanoBot

34.7K

Ultra-lightweight OpenClaw in Python. 99% less code, full agent capabilities. Supports MCP, multi-model (OpenAI, Anthropic, Gemini, Ollama), memory, cron, sub-agents. Install: pip install nanobot-ai.

ZeroClaw

27.9K

Fast, small, and fully autonomous AI assistant infrastructure. Deploy anywhere, swap anything. Written in Rust with extreme performance focus — the infrastructure layer for self-hosted AI agents.

PicoClaw

25.4K

Go-based agent running on $10 hardware. <10MB RAM, <1s boot time. 99% less memory than OpenClaw. Supports x86_64, ARM64, MIPS, RISC-V, and LoongArch architectures.

NanoClaw

24.2K

Lightweight alternative to OpenClaw that runs in containers for security. Connects to WhatsApp, Telegram, Slack, Discord, Gmail. Built on Anthropic Agents SDK with memory and scheduled jobs.

MicroClaw

576

Agentic AI assistant built with Rust. Runs on <1MB RAM targeting $2-5 MCU hardware like ESP32. The smallest member of the Claw family for sensor-level embedded AI.

EdgeClaw

155

Edge-Cloud Collaborative AI Assistant built on OpenClaw. Three-tier privacy system (Passthrough/Desensitization/Local) with dual-engine edge detector. Keeps sensitive data local while routing 80% of requests to cost-effective cloud models. By THUNLP, RUC, OpenBMB.

PythonClaw

17

OpenClaw reimagined in pure Python. Autonomous AI agent with memory, RAG, skills, web dashboard, voice input, and multi-channel support (Telegram, etc.).

ClawX

4.9K

Desktop app providing a graphical interface for OpenClaw AI agents. Turns CLI-based AI orchestration into a visual desktop experience without using the terminal.

MetaClaw

1.9K

Self-learning agent that evolves from every conversation. LoRA-based continual learning + reinforcement learning, no GPU cluster needed. Supports OpenClaw, NanoBot, PicoClaw backends.

Clawith

1.6K

OpenClaw for Teams. Multi-agent collaboration with persistent identity, long-term memory, and autonomous 'Aware' consciousness system. 6 trigger types: cron, once, interval, poll, on_message, webhook.

EvoScientist

1K

Self-evolving multi-agent AI research system. 6 sub-agents (plan, research, code, debug, analyze, write) for end-to-end scientific discovery. #1 on DeepResearch Bench II. ICAIS 2025 Best Paper Award.

MedgeClaw

912

AI research assistant for biomedicine. Built on OpenClaw + Claude Code with 140 K-Dense Scientific Skills. Covers RNA-seq, drug discovery, clinical analysis. Integrated RStudio & JupyterLab.

LabClaw

762

Operating layer for LabOS — Stanford-Princeton AI Co-Scientists project. Automated scientific co-discovery workflows for laboratory research.

ClawBio

453

The first bioinformatics-native AI agent skill library. Local-first, reproducible, built on OpenClaw. Covers genomics, population genetics, and equity-focused bioinformatics workflows.

BioClaw

221

AI-powered bioinformatics research assistant built on OpenClaw. Integrates PubMed literature search and PyMOL molecular visualization for streamlined biological research workflows.

OmicsClaw

64

Multi-omics AI analysis tool from TianGz Lab. Focused on genomics, transcriptomics, and proteomics data processing with intelligent agent workflows.

MedClaw

8

Early-stage medical AI project exploring agent-based approaches for clinical decision support and medical data analysis.

MolClaw

6

Light, practical, memory-enabled AI orchestrator for science. Built on NanoClaw. Adds OpenAI/OpenRouter providers, Discord/WhatsApp channels, runtime skills, durable session memory, and real-time agent execution dashboard.

OpenMAIC

7.6K

Open Multi-Agent Interactive Classroom by Tsinghua University. One-click immersive AI classroom with AI teachers and peers. Slides, quizzes, whiteboard, PBL. Published in JCST'26.

AutoBA

222

An AI agent for fully automated multi-omic analyses. Supports RNA-seq, scRNA-seq, spatial transcriptomics, WGS/WES, and ChIP-seq with automated code repair.

CellVoyager

154

AI CompBio agent that autonomously analyzes biological data and generates new insights. From Stanford Zou Group. Published in Nature Methods. Specializes in scRNA-seq with self-debugging and hypothesis generation.

SpatialAgent

153

An AI agent for spatial biology by Genentech. Processes multimodal spatial genomics data for research insights.

CRISPR-GPT

147

LLM agent for CRISPR genome engineering. Assists with guide RNA design, experiment planning, and protocol optimization.

BioMaster

89

AI agent system for various bioinformatics tasks with specialized agent coordination. From the same group as POPGENAGENT.

CellAgent

12

LLM-driven multi-agent framework for automated scRNA-seq analysis. Three-role architecture: Planner, Executor, and Evaluator for single-cell RNA sequencing workflows.

PopGenAgent

9

Tool-aware, reproducible, report-oriented AI workflows for population genomics. Template-driven execution with publication-quality figures, full provenance tracking, and cost-aware LLM routing.

CARIBOU

2

Computational AI Research Interface for Bioinformatics, Omics, and Unifying Agents. Multi-agent bioinformatics system by OpenTechBio.

Virtual Lab

649

A virtual lab of LLM agents for science research. Multi-agent system for nanobody design with principal investigator agent coordination.

MDCrow

230

Molecular dynamics simulations with an LLM agent. Automates simulation setup, execution, and analysis using natural language.

ChemGraph

79

Agentic framework for computational chemistry and materials science workflows. From Argonne National Laboratory (ALCF). Orchestrates chemistry simulation pipelines.

AIAgents4Pharma

71

Multi-agent platform for pharmaceutical R&D. Covers drug discovery, drug development, and clinical pipeline automation. Built by VirtualPatientEngine.

RD-Agent

11.9K

Microsoft R&D automation platform. AI-driven data and model research — automates hypothesis generation, experiment design, and iterative improvement for industrial and scientific R&D.

AutoResearchClaw

7180

Fully autonomous, self-evolving research framework: from a one-line idea to a conference-level paper. 23-stage pipeline with multi-agent debate, self-healing error correction, citation verification, and hardware-adaptive execution. Compatible with OpenClaw and MetaClaw.

AI-Researcher

4.9K

Autonomous scientific innovation system from HKUDS. NeurIPS 2025 paper. End-to-end research automation: literature review, hypothesis generation, experiment design, and paper writing. Production version at novix.science.

AI-Scientist-v2

2.3K

Sakana AI's autonomous scientific discovery system. Workshop-level paper generation via agentic tree search. End-to-end: idea → experiment → paper. Successor to the 10K-star AI-Scientist v1.

DATAGEN

1.7K

AI-driven multi-agent research assistant automating hypothesis generation, data analysis, and report writing. Full research pipeline from question to publication-ready report.

Dr. Claw

576

AI Research IDE with built-in "AI Doctors" assistants. Full research lifecycle: Survey → Ideation → Experiment → Publication → Promotion. 100+ research skills, auto pipeline planning, real-time task tracking, LaTeX rendering, Git integration. PWA-ready.

OpenAGS

43

Autonomous Generalist Scientist — AI agent targeting all scientific fields. Broad-scope autonomous research from hypothesis to verification.

Open Co-Scientist

16

Open-source adaptation of Google DeepMind's AI Co-Scientist. Generates, reviews, ranks, and evolves research hypotheses using multi-agent architecture.

OpenLens AI

249

Fully autonomous multimodal research agent. Combines vision and text understanding for scientific discovery. Chinese academic origin with bilingual support.

BioAgents

114

AI scientist framework for autonomous deep research in biological sciences. Multi-agent system combining literature analysis with data scientist agents for iterative scientific discovery.

BioDiscoveryAgent

99

LLM-based AI agent for closed-loop design of genetic perturbation experiments. Autonomous reasoning for biological discovery.

SR-Scientist

35

Scientific equation discovery with agentic AI. Published at ICLR 2026. Symbolic regression via AI agents from GAIR Lab (Shanghai Jiao Tong University).