The OpenClaw Ecosystem for Scientific Research

OpenClaw

352.9K

The core platform. Personal AI assistant connecting 20+ messaging apps (WhatsApp, Telegram, Slack, Discord, Signal, iMessage, Teams, Matrix, Feishu, LINE). Voice support on macOS/iOS/Android with live Canvas rendering.

Hermes Agent

41.8K

The self-improving AI agent by Nous Research. Built-in learning loop — creates skills from experience, improves during use, persists knowledge across sessions. Key differentiator: per-model parser adaptation that makes local open-source models work reliably with tool calls where other frameworks fail.

NanoBot

38.7K

Ultra-lightweight OpenClaw in Python. 99% less code, full agent capabilities. Supports MCP, multi-model (OpenAI, Anthropic, Gemini, Ollama), memory, cron, sub-agents. Install: pip install nanobot-ai.

ZeroClaw

29.8K

Fast, small, and fully autonomous AI assistant infrastructure. Deploy anywhere, swap anything. Written in Rust with extreme performance focus — the infrastructure layer for self-hosted AI agents.

PicoClaw

27.9K

Tiny, fast, and deployable anywhere. Ultra-efficient AI assistant written in Go by Sipeed. Designed for edge devices and resource-constrained environments. Inspired by NanoBot.

NanoClaw

27K

Lightweight alternative to OpenClaw that runs in containers for security. Connects to WhatsApp, Telegram, Slack, Discord, Gmail. Built on Anthropic Agents SDK with memory and scheduled jobs.

NemoClaw

18.8K

NVIDIA official reference stack for running OpenClaw securely inside NVIDIA OpenShell sandbox. Managed inference with Nemotron open-source models. Essential for labs running autonomous agents on GPU servers.

IronClaw

11.6K

Rust implementation of OpenClaw focused on privacy and security. Memory-safe architecture with Rust's ownership model, built by NEAR AI. Ideal for sensitive research environments requiring data isolation and high performance.

OpenHarness

8K

Open Agent Harness from HKUDS (NanoBot team). Runtime environment and execution framework for AI agents. 615 stars in 1 day.

NullClaw

7.1K

Fastest, smallest, fully autonomous AI assistant infrastructure written in Zig. Part of the Null ecosystem (NullHub UI, NullWatch observability, NullTickets task tracking). Extreme performance with minimal resource footprint.

autoagent

3.9K

Autonomous harness engineering. Self-configuring agent runtime that adapts to your workflow. 560 stars in 24 hours.

EdgeClaw

1.2K

Edge-Cloud Collaborative AI Agent built on OpenClaw — bringing the Claude Code experience to open source. v2.0 features ClawXMemory (multi-layered structured long-term memory with proactive reasoning) and ClawXRouter (LLM-as-Judge cost-saving router achieving 58% savings). Three-tier privacy (S1 Passthrough / S2 Desensitization / S3 Local), visual Dashboard, zero-config setup. By THUNLP, RUC, OpenBMB.

MicroClaw

636

Agentic AI assistant built with Rust. Runs on <1MB RAM targeting $2-5 MCU hardware like ESP32. The smallest member of the Claw family for sensor-level embedded AI.

FastClaw

533

Faster and lighter OpenClaw alternative written in Go. Focused on speed, simplicity, and low resource usage. Quick to deploy for researchers who want minimal setup overhead.

Edict

14.8K

Multi-agent orchestration inspired by China's Imperial Three Departments and Six Ministries system. 9 specialized AI agents with real-time dashboard, model config, and full audit trails. You are the Emperor — issue edicts, your AI ministers execute.

ClawX

6.3K

Desktop app providing a graphical interface for OpenClaw AI agents. Turns CLI-based AI orchestration into a visual desktop experience without using the terminal.

Open Multi-Agent

5.5K

TypeScript multi-agent framework. One runTeam() call from goal to result. Auto task decomposition, parallel execution. 3 dependencies, deploys anywhere Node.js runs. 4K stars in 4 days.

OpenSpace

4.8K

Agent optimization framework from HKUDS (NanoBot team). Makes agents smarter, lower-cost, and self-evolving. Useful for improving any science agent's performance over time.

ClawTeam

🔥 New

4.6K

Agent Swarm Intelligence — one command, full automation. Agents spawn swarms, delegate tasks, and deliver results. Supports Claude Code, Codex, OpenClaw, nanobot, Cursor. From HKUDS (nanobot team).

HiClaw

4K

Collaborative Multi-Agent OS by Alibaba. Transparent, human-in-the-loop task coordination via Matrix rooms. Open-source agent team orchestration for enterprise workflows.

Open-source managed agents platform. Turn coding agents into real teammates — assign tasks, track progress, compound skills. Agents show up on boards, post comments, report blockers autonomously. Works with Claude Code, Codex, OpenClaw. Self-hosted or cloud (multica.ai).

MetaClaw

3.5K

Self-learning agent that evolves from every conversation. LoRA-based continual learning + reinforcement learning, no GPU cluster needed. Supports OpenClaw, NanoBot, PicoClaw backends.

TinyAGI

3.5K

Agent teams orchestrator for One Person Company. Coordinate multiple specialized agents for solo founders and indie researchers. Formerly TinyClaw.

Clawith

3K

OpenClaw for Teams. Multi-agent collaboration with persistent identity, long-term memory, and autonomous 'Aware' consciousness system. 6 trigger types: cron, once, interval, poll, on_message, webhook.

ClawTeam fork with deep OpenClaw integration. Default openclaw agent, per-agent session isolation, exec approval auto-config, production-hardened spawn backends. All upstream fixes synced.

The ultimate OpenClaw harness. Browser-based setup wizard, self-healing watchdog, Git-backed rollback, multi-agent management, prompt hardening, and one-click Railway/Render deploy. 892 stars, 440 tests. Zero SSH rescue missions.

ClawManager

531

Kubernetes-first control plane for managing OpenClaw and Linux desktop runtimes at team and cluster scale. Web UI for multi-instance orchestration.

ArgusBot

294

24/7 supervisor Agent for Codex CLI and Claude Code CLI. Keeps agents running, reviewing, and planning until the job is actually done. Useful for overnight experiments and long-running analysis tasks.

MagiClaw

107

Conversational command center for scientific agent teams. From SJTU SAI Agents. Orchestrate multiple research agents through natural language dialogue.

EvoScientist

2.8K

Self-evolving multi-agent AI research system. 6 sub-agents (plan, research, code, debug, analyze, write) for end-to-end scientific discovery. #1 on DeepResearch Bench II. ICAIS 2025 Best Paper Award.

LabClaw

945

Operating layer for LabOS — Stanford-Princeton AI Co-Scientists project. Automated scientific co-discovery workflows for laboratory research.

MedgeClaw

856

AI research assistant for biomedicine built on Claude Code with 140 K-Dense scientific skills. Real-time research dashboard, RStudio (:8787), JupyterLab (:8888), and Feishu rich card output.

ClawBio

678

The first bioinformatics-native AI agent skill library. Local-first, reproducible, built on OpenClaw. Covers genomics, population genetics, and equity-focused bioinformatics workflows.

BioClaw

323

AI-powered bioinformatics research assistant built on OpenClaw. Integrates PubMed literature search and PyMOL molecular visualization for streamlined biological research workflows.

Open-source self-evolving personal health copilot. Medical consultation support, meal planning, report interpretation, chronic-care follow-up, wearable data analytics. Supports clinical data, medical imaging, and omics evidence. Streamlit + Feishu + CLI.

STELLA

124

Self-evolving multimodal agent platform for biomedical research. From Princeton/Stanford/UCLA. Published on bioRxiv and arXiv. Live demo at stella-agent.com.

OmicsClaw

114

Multi-omics AI analysis tool from TianGz Lab. Focused on genomics, transcriptomics, and proteomics data processing with intelligent agent workflows.

MedClaw (zteyesreal)

60

Early-stage medical AI project exploring agent-based approaches for clinical decision support and medical data analysis.

Biomni

2.9K

General-purpose biomedical AI agent from Stanford SNAP Lab. Broad coverage across biomedical tasks with a unified agent architecture.

PantheonOS

388

Evolvable, distributed agent framework for data science from the dynamo/Spateo team. Specialized in single-cell and spatial transcriptomics workflows.

AutoBA

226

An AI agent for fully automated multi-omic analyses. Supports RNA-seq, scRNA-seq, spatial transcriptomics, WGS/WES, and ChIP-seq with automated code repair.

CellVoyager

202

AI CompBio agent that autonomously analyzes biological data and generates new insights. From Stanford Zou Group. Published in Nature Methods. Specializes in scRNA-seq with self-debugging and hypothesis generation.

SpatialAgent

158

An AI agent for spatial biology by Genentech. Processes multimodal spatial genomics data for research insights.

CRISPR-GPT

156

LLM agent for CRISPR genome engineering. Assists with guide RNA design, experiment planning, and protocol optimization.

BioMaster

91

AI agent system for various bioinformatics tasks with specialized agent coordination. From the same group as POPGENAGENT.

Biomedical AI agent published in Nature Biomedical Engineering. Dormant since Feb 2025 but with top-tier publication backing.

ChemCrow

894

Pioneering chemistry AI agent (2023) from ur-whitelab. LangChain-based, cited in official docs. The foundational project that inspired MDCrow and the broader science agent movement.

Virtual Lab

660

A virtual lab of LLM agents for science research. Multi-agent system for nanobody design with principal investigator agent coordination.

MDCrow

234

Molecular dynamics simulations with an LLM agent. Automates simulation setup, execution, and analysis using natural language.

OriGene

203

Self-evolving virtual disease biologist for mechanism-guided therapeutic target discovery. Automates disease mechanism analysis and drug target identification.

Agentic RAG for drug intelligence: 57 skills, 15 task categories — DTI, ADR, DDI, pharmacogenomics, repurposing. Powered by LangGraph.

ChemGraph

90

Agentic framework for computational chemistry and materials science workflows. From Argonne National Laboratory (ALCF). Orchestrates chemistry simulation pipelines.

AIAgents4Pharma

76

Multi-agent platform for pharmaceutical R&D. Covers drug discovery, drug development, and clinical pipeline automation. Built by VirtualPatientEngine.

AI Research Assistant for Accelerated Drug Discovery. Built with Rust for high performance. Covers compound screening, ADMET prediction, and lead optimization workflows.

Omniscient multi-modal agentic workspace for scientific discovery. Cheminformatics (RDKit), protein folding (ESMFold), molecular docking, autonomous RAG. XML-Regex dual-track routing, runtime sandbox for data visualization. From Beijing 1st Biotech + PLA General Hospital.

By Andrej Karpathy. Give an AI agent a small but real LLM training setup and let it experiment autonomously overnight. Single GPU, ~100 experiments/night. Works with Claude Code, Codex, or any agent.

Tongyi Deep Research by Alibaba. Leading open-source deep research agent (30.5B params, 3.3B activated). State-of-the-art on Humanity's Last Exam, BrowseComp, and 4 more benchmarks. ReAct and IterResearch inference modes.

RD-Agent

12.4K

Microsoft R&D automation platform. AI-driven data and model research — automates hypothesis generation, experiment design, and iterative improvement for industrial and scientific R&D.

End-to-end autonomous research workflow: Literature Review → Experimentation → Report Writing. Specialized LLM agents collaborate via arXiv, HuggingFace, Python, LaTeX. Includes AgentRxiv for cumulative cross-agent research.

AI-Scientist-v2

5.3K

Workshop-level automated scientific discovery via agentic tree search. By Sakana AI. Autonomously generates research papers through iterative hypothesis testing and experimentation.

AI-Researcher

5.1K

Autonomous scientific innovation system from HKUDS. NeurIPS 2025 paper. End-to-end research automation: literature review, hypothesis generation, experiment design, and paper writing. Production version at novix.science.

DATAGEN

1.7K

AI-driven multi-agent research assistant automating hypothesis generation, data analysis, and report writing. Full research pipeline from question to publication-ready report.

Open-source, cost-efficient alternative to OpenAI's Deep Research, built on AutoAgent framework by HKUDS. Universal LLM support (OpenAI, Anthropic, DeepSeek, vLLM, Grok). One-click launch.

Prismer

893

Open-source alternative to OpenAI's Prism. Unified platform for AI-powered paper reading, learning, and research knowledge management.

NanoResearch

698

Autonomous AI research assistant built on NanoBot. From idea to paper with automated literature review, experiment design, and writing.

EurekaClaw

660

Self-evolving AI research agent by the EurekaClaw team. Autonomous scientific discovery with persistent memory and tool-use capabilities.

Fully open agentic LLM (30B-A3B) for long-horizon deep research by TIGER-AI-Lab. 54.8% on BrowseComp-Plus, surpassing GPT-4.1, Claude-Opus-4, Gemini-2.5-Pro. Open dataset (96K trajectories), model, and training code. Adopted by NVIDIA Nemotron.

Personalized multi-agent system that researches 24/7 on your scientific problem. From hypothesis generation through experimentation to publication-ready manuscripts. Dynamic workflows, fully customizable agents, human-in-the-loop.

A self-hostable AI research workspace with grounded chat, paper study tools, and scientific skill execution — all anchored to your local files.

AI Scientist Ecosystem by Tsinghua FIB Lab and Zhongguancun Academy. 7 core papers covering co-evolving ecosystem, expert knowledge integration, high-impact research question identification, and automated experiment design.

Autonomous research framework from University of Chicago Human+AI Lab. Input a title, domain, and hypothesis — agents handle literature review, experiment design, code execution, analysis, and LaTeX paper writing. Supports Claude Code, Codex, and Gemini CLI. IdeaHub platform for community research ideas. Docker-ready, domain-agnostic.

OpenAGS

50

Autonomous Generalist Scientist — AI agent targeting all scientific fields. Broad-scope autonomous research from hypothesis to verification.

Auto-Research-In-Sleep — let Claude Code do research while you sleep. Lightweight Markdown-only skills for autonomous ML research: cross-model review loops, idea discovery, experiment automation. Zero dependencies, works with OpenClaw, Codex, or any LLM agent.

DeepScientist

1.9K

Local-first AI research studio. 15-minute setup, one repo per research quest, visible progress, human takeover anytime. Published at ICLR 2026.

Memento-Skills

1K

Let Agents Design Agents. A meta-framework where AI agents create, test, and evolve new skills and agents autonomously. Unlike traditional skill libraries, the skills here are machine-authored.

Dr. Claw

825

AI Research IDE with built-in "AI Doctors" assistants. Full research lifecycle: Survey → Ideation → Experiment → Publication → Promotion. 100+ research skills, auto pipeline planning, real-time task tracking, LaTeX rendering, Git integration. PWA-ready.

ScienceClaw (beita6969)

567

Self-evolving AI research colleague. 285 skills that grow at runtime — the agent writes new skills based on your usage patterns. 4-layer persistent memory with LanceDB, 1hr+ session timeout, zero-hallucination citation protocol.

ScienceClaw (TaichuAI)

475

Personal research assistant built with LangChain DeepAgents and AIO Sandbox. A new architecture beyond OpenClaw, offering stronger security, better transparency, and a more user-friendly experience.

Automated scientific discovery system by Allen AI. LLM-as-a-mutator generates experiment ideas from paper+code combinations, then creates, runs, and debugs experiments in containers. Writes reports and meta-analyses.

OpenLens AI

258

Fully autonomous multimodal research agent. Combines vision and text understanding for scientific discovery. Chinese academic origin with bilingual support.

A 7x24 AI research team for academics with 244 skills and 13 agent templates, designed to eliminate repetitive lab work so researchers can focus on thinking.

ScienceClaw (MIT LAMM)

142

Open-source AI agent swarm for crowdsourced scientific discovery. 300+ interoperable tools, plannerless ArtifactReactor coordination, DAG lineage tracking. Agents self-coordinate across institutions via Infinite platform (lamm.mit.edu/infinite). Solving real problems: peptide binder design, ceramic discovery, cross-disciplinary pattern recognition. From MIT LAMM Lab (Markus Buehler). Genesis Mission backed.

BioAgents

124

AI scientist framework for autonomous deep research in biological sciences. Multi-agent system combining literature analysis with data scientist agents for iterative scientific discovery.

BioDiscoveryAgent

102

LLM-based AI agent for closed-loop design of genetic perturbation experiments. Autonomous reasoning for biological discovery.

StatsClaw

55

Multi-agent workflow for statistical software development. Information-isolated agents: builder (no ground truth), simulator (no algorithm), tester (independent validation). Cambridge + Stanford.

SciClaw (drpedapati)

51

Paired-scientist AI assistant for reproducible research. Lightweight Go runtime, lifecycle hooks, manuscript integration, 12 baseline scientific skills. PicoClaw-compatible. Homebrew installable.

AutoResearchClaw

10.8K

Fully autonomous, self-evolving research framework: from a one-line idea to a conference-level paper. 23-stage pipeline with multi-agent debate, self-healing error correction, citation verification, and hardware-adaptive execution. Compatible with OpenClaw and MetaClaw.

Full-stack AI research assistant — "In the AI era, why can't everyone be a PI?" Supports extensible skills, literature review, note-taking, experiment tracking, and paper writing end to end. 350+ plugins available.

Turning every citation into explainable impact. Citation analysis and impact assessment tool for academic research — tracks citation networks, measures influence, and provides explainable bibliometric insights.

Personal AI assistant built for research. Fast setup, local or cloud, integrates with chat apps. Streamlines literature review, note-taking, experiment tracking, and paper writing end to end.

OpenClaw skill for paper search-review-critique expert-agent. Generates research workflows for specific topics (demo: Scientific ML and 3D geometry).

Agent that turns academic papers into publication-ready diagrams, posters, videos, and more. Visual research communication tool — automates the creation of conference materials from your manuscripts.

Self-hosted AI assistant for academic research — manages papers, searches literature, tracks deadlines.

Standalone Electron desktop app combining AI-powered paper management, interactive reading notes, and research idea generation — no browser or server required.

Transform your PDF paper library into a cross-referenced, queryable citation graph database. AI agents extract metadata, citations, and context from PDFs, then fuzzy-match across papers. Dual environment: Main (ingest) + Query (Haiku-powered, read-only). 41 commits, actively developed.

OpenMAIC

14.7K

Open Multi-Agent Interactive Classroom by Tsinghua University. One-click immersive AI classroom with AI teachers and peers. Slides, quizzes, whiteboard, PBL. Published in JCST'26.

Multimodal math learning assistant for middle and high school. Solving workspace, weakness diagnosis, knowledge graphs, error graphs, auto-summaries. Supports WeChat, QQ, Feishu, Telegram, Discord. From Renmin University.

Real-world benchmarks for AI coding agents. 23 tasks across productivity, research, writing, coding, analysis, email, memory, and skills. Public leaderboard at pinchbench.com. Auto-grading + LLM judge. Tests what actually matters: tool usage, multi-step reasoning, and practical outcomes.

End-to-end evaluation suite for autonomous agents. 300 human-verified tasks across 9 categories (service orchestration, multimodal perception, multi-turn dialogue). Trajectory-aware grading over 2,159 rubrics. Tests Completion, Safety, and Robustness. Used by Qwen, GLM, MiniMax.

Benchmark for evaluating whether AI agents can independently conduct scientific research. 40 real-science tasks across 10 disciplines (Astronomy, Chemistry, Physics, Life, etc.), two-stage pipeline (autonomous research + LLM peer-review scoring), expert-annotated checklists. Score 50 = match human paper, 70+ = surpass it. Supports Claude Code, Codex CLI, OpenClaw, NanoBot, EvoScientist. From Shanghai Jiao Tong University.

AI agent evaluation suite for bioinformatics. Benchmarks LLM agents on real bioinformatics tasks. Covers sequence analysis, genomics workflows, and computational biology pipelines. arXiv paper.

Safety benchmark for personal AI agents under realistic prompt injection. 120 adversarial test cases across 5 harm domains, 3 attack vectors, and 5 harmful action types. Tested Claude, Gemini, GPT-5.1, DeepSeek on OpenClaw/Nanobot/NemoClaw scaffolds. Key finding: chat safety ≠ agent safety.

Security scanner for Agent Skills — the npm audit for the Agent-Native ecosystem. Scans for shell injection, hardcoded secrets, unpinned dependencies, excessive permissions, and prompt injection risks. Rust CLI with GitHub App integration. Inspired by the ClawHavoc incident (341 malicious skills).